Hillstream BioPharma (NASDAQ:HILS) and Synlogic (NASDAQ:SYBX) Head-To-Head Review

Hillstream BioPharma (NASDAQ:HILS) and Synlogic (NASDAQ:SYBX) are both small-cap medical companies, but which is the superior business? We will compare the two companies based on the strength of their earnings, dividends, risk, institutional ownership, valuation, profitability and analyst recommendations.

Analyst Recommendations

This is a summary of recent ratings and price targets for Hillstream BioPharma and Synlogic, as provided by MarketBeat.

	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Hillstream BioPharma	0	0	0	0	0.00
Synlogic	0	4	1	0	2.20

Synlogic has a consensus price target of $30.00, suggesting a potential upside of 2,035.23%. Given Synlogic’s stronger consensus rating and higher probable upside, analysts plainly believe Synlogic is more favorable than Hillstream BioPharma.

Profitability

This table compares Hillstream BioPharma and Synlogic’s net margins, return on equity and return on assets.

	Net Margins	Return on Equity	Return on Assets
Hillstream BioPharma	N/A	-188.44%	-149.61%
Synlogic	-2,284.65%	-207.84%	-114.81%

Earnings and Valuation

This table compares Hillstream BioPharma and Synlogic”s gross revenue, earnings per share and valuation.

	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Hillstream BioPharma	N/A	N/A	-$8.47 million	($0.72)	-3.47
Synlogic	$3.37 million	4.88	-$57.28 million	($4.16)	-0.34

Hillstream BioPharma has higher earnings, but lower revenue than Synlogic. Hillstream BioPharma is trading at a lower price-to-earnings ratio than Synlogic, indicating that it is currently the more affordable of the two stocks.

Insider & Institutional Ownership

13.4% of Hillstream BioPharma shares are owned by institutional investors. Comparatively, 63.4% of Synlogic shares are owned by institutional investors. 30.2% of Hillstream BioPharma shares are owned by company insiders. Comparatively, 3.0% of Synlogic shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Volatility and Risk

Hillstream BioPharma has a beta of 3.08, indicating that its stock price is 208% more volatile than the S&P 500. Comparatively, Synlogic has a beta of 0.84, indicating that its stock price is 16% less volatile than the S&P 500.

Summary

Synlogic beats Hillstream BioPharma on 7 of the 13 factors compared between the two stocks.

About Hillstream BioPharma

Hillstream BioPharma, Inc., a pre-clinical biotechnology company, develops novel therapeutic candidates targeting ferroptosis, an anti-cancer mechanism resulting in iron mediated cell death (IMCD) and targeted immuno-oncology novel biologics for the treatment drug resistant cancers. The company's product candidate is HSB-1216, an IMCD inducer targeting solid tumors. It also develops HSB-3215, an anti-HER2 monoclonal antibody candidate; and HSB-1940, a Quatrabody that is a proprietary IO biologic in development targeting PD-1. The company was incorporated in 2017 and is based in Bridgewater, New Jersey.

About Synlogic

Synlogic, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of synthetic biotics to treat metabolic diseases in the United States. Its pipeline include SYNB1618, an orally administered, non-systemically absorbed drug candidate to treat phenylketonuria; SYNB1934, an orally administered, non-systemically absorbed drug candidate, which is in Phase III clinical trial to treat phenylketonuria; SYNB1353, an orally administered, non-systemically absorbed drug candidate, which is in Phase I clinical to treat homocystinuria; SYNB8802, an orally administered, non-systemically absorbed drug candidate that is in Phase II clinical trial for the treatment of enteric hyperoxaluria; and SYNB2081 to lower uric acid for the potential treatment of gout. The company has a collaboration agreement with F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc. for the research and pre-clinical development of a synthetic biotic medicine for the treatment of inflammatory bowel disease; and Ginkgo Bioworks, Inc. Synlogic, Inc. is based in Cambridge, Massachusetts.